Blar i forfatter "Hubert, Madlen"

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    • Metallo-β-Lactamase Inhibitor Phosphonamidate Monoesters 

      Palica, Katarzyna; Vorácová, Manuela; Skagseth, Susann; Andersson Rasmussen, Anna; Allander, Lisa; Hubert, Madlen; Sandegren, Linus; Leiros, Hanna-Kirsti S.; Andersson, Hanna; Erdélyi, Máté (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-01-25)
      Being the second leading cause of death and the leading cause of disability-adjusted life years worldwide, infectious diseases remain-contrary to earlier predictions-a major consideration for the public health of the 21st century. Resistance development of microbes to antimicrobial drugs constitutes a large part of this devastating problem. The most widely spread mechanism of bacterial resistance ...

    • NMR Backbone Assignment of VIM-2 and Identification of the Active Enantiomer of a Potential Inhibitor 

      Wieske, Lianne H. E.; Bogaerts, Jonathan; Leding, Albin A. M.; Wilcox, Scott; Rasmussen, Anna Andersson; Leszczak, Kinga; Turunen, Lotta; Herrebout, Wouter A.; Hubert, Madlen; Bayer, Annette; Erdelyi, Mate (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-01-28)
      Carbapenem resistance caused by metallo-β-lactamases is a serious global challenge that, if not tackled efficiently, is expected to lead to millions of deaths in the coming decades. Verona-integron encoded metallo-β-lactamase 2 (VIM-2) is a bacterial enzyme that has been reported from multidrug-resistant nosocomial isolates of Pseudomonas aeruginosa and other Gram-negative pathogens. As it hydrolyzes ...